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PMC 2709701

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In some embodiments, the otic formulation comprises between about 0.0001% to about 10% by weight of the weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

The shared essential effect of cytoprotective agents, which was originally noted in the stomach, is regarded as a rapid endothelial protective mechanism that can be used to prevent and resolve adjacent ischemic mucosal lesions[12-16]

Although the permeability value of targeted nanocarriers were lower in case of BBB models on the inserts with 0.4 m pore size membranes, the significant difference between the non-targeted and targeted groups remained the same and the penetration of marker molecules across the BBB model on inserts with 3 m pore-size membranes or 0.4 m pore-size membranes were also similar